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I am seeing peak tailing with my LC method, specifically with early eluting compounds. What could be the cause of this?

TROUBLESHOOTING

HPLC UHPLC

Last Updated: 5/4/2014

Extra-column effects may be the cause of peak tailing with early eluters. Ensure that your system has been optimized for the column that you are using. This is especially critical with Kinetex Core-Shell columns. Refer to our System Optimization Manual for further information.

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