Trending Applications

Trending Webinars and Webcasts

Frequently Asked Questions (FAQs) for Small Molecule Analysis

What are the advantages of analyzing my basic active pharmaceutical ingredient (API) at high pH? »
Can I inject the solution from my dissolution study directly onto my reversed phase HPLC column? »
Is there anything I can do about protein/peptide carryover? »

Advancing Small Molecule HPLC Analysis

Most pharmaceutical drugs on the market are in the form of small molecules. Small molecules and their metabolites are commonly studied by HPLC chromatography where they are analyzed, separated, and purified with HPLC columns ».

HPLC analysis of small molecules mostly involves reversed phase HPLC chromatography but can also engage normal phase HPLC chromatography and ion-exchange HPLC chromatography. HPLC columns typically contain spherical silica beads of a particular particle size and bonded stationary phase. The evolution of HPLC chromatography shows a trend for HPLC columns to possess smaller particle sizes, offer high efficiency and lower instrument backpressure.

Product Spotlight

Kinetex Core-shell Technology Columns »
Dramatically improve resolution and efficiency for small molecules with high performance core-shell particles
Luna Omega LC Columns »
Achieve better peak shape and separation muscle for small molecules with thermally modified fully porous particles

Technical Guide Spotlight

Drugs and Metabolism Guide »

USP/EP Guide »

Method Development and Product Selection

Explore the Pharmaceutical Resources Center »

Find the latest webinars, technical notes, and guides for pharmaceutical analysis.

Learn more »

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<h2>Trending Applications</h2>

<ul class="iapps">
	<li><a href="/Application/Detail/23587" target="_blank">Antibiotics »</a></li>
	<li><a href="/Application/Detail/23727" target="_blank">Beta-Blockers »</a></li>
	<li><a href="/Application/Detail/23036" target="_blank">Cold Medicine »</a></li>
	<li><a href="/Application/Detail/22813" target="_blank">Pharma Mix »</a></li>
	<li><a href="/info/page/nitrosaminesresources" target="_blank">Genotoxic Nitrosamines »</a></li>
</ul>

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	<li><a href="/Application/Detail/22798" target="_blank">Statin Drugs »</a></li>
	<li><a href="/Application/Detail/23640" target="_blank">Chiral Amphetamines »</a></li>
	<li><a href="/Application/Detail/23177" target="_blank">Atorvastatin and Related E »</a></li>
	<li><a href="/Application/Detail/15926" target="_blank">Solvents »</a></li>
</ul>

<h2>Trending Webinars and Webcasts</h2>

<p class="webtitle"><a href="/info/form/16uhplcwebinar" target="_blank">UHPLC: Small Particle Solutions for Big Chromatography Challenges »</a></p>

<p class="webtitle"><a href="/info/form/2014biphenylenoteintl" target="_blank">LC:Transforming Small Molecule Method Development with Core-shell Technology  »</a></p>

<h2>Frequently Asked Questions (FAQs) for Small Molecule Analysis</h2>

<ul class="ifaqs">
	<li><a href="/FAQ/Details/5192ba75-1f6d-4bf6-982a-a3b0e2d88e67/what-are-the-advantages-of-analyzing-my-basic-api-at-high-ph" target="_blank">What are the advantages of analyzing my basic active pharmaceutical ingredient (API) at high pH? »</a></li>
	<li><a href="/FAQ/Details/547e446f-ebd2-4b0e-acf0-536beaf3fba3?" target="_blank">Can I inject the solution from my dissolution study directly onto my reversed phase HPLC column? »</a></li>
	<li><a href="/FAQ/Details/0a953ad4-78c8-40c4-aebb-f4a6a29d9da4/is-there-anything-i-can-do-about-protein-peptide-carryover" target="_blank">Is there anything I can do about protein/peptide carryover? »</a></li>
</ul>

<hr />
<h2>Advancing Small Molecule HPLC Analysis</h2>

<p style="margin-top:-10px;">Most pharmaceutical drugs on the market are in the form of small molecules. Small molecules and their metabolites are commonly studied by HPLC chromatography where they are analyzed, separated, and purified with <a class="tech" href="/hplc-column/reversed-phase-hplc-column">HPLC columns »</a>.</p>

<p>HPLC analysis of small molecules mostly involves reversed phase HPLC chromatography but can also engage normal phase HPLC chromatography and ion-exchange HPLC chromatography. HPLC columns typically contain spherical silica beads of a particular particle size and bonded stationary phase. The evolution of HPLC chromatography shows a trend for HPLC columns to possess smaller particle sizes, offer high efficiency and lower instrument backpressure.</p>

<h2>Product Spotlight</h2>

<ul class="prodlight">
	<li class="knxlc"><a href="/kinetex" target="_blank"><img border="0" class="spotlightimg" height="115" id="knxcorelcpharm" src="//az621941.vo.msecnd.net/cdn/Content/Images/kinetexNew/phaseInformation/phase_evo_c18.png" /></a> <a class="tech" href="/kinetex">Kinetex Core-shell Technology Columns »</a><br />
	Dramatically improve resolution and efficiency for small molecules with high performance core-shell particles</li>
	<li class="lunlc"><a href="/Products/HPLCDetail/luna" target="_blank"><img border="0" class="spotlightimg" height="115" id="lunaomegalcpharm" src="/webimage/luna-omega-large.png" /></a> <a class="tech" href="/Products/HPLCDetail/luna">Luna Omega LC Columns »</a><br />
	Achieve better peak shape and separation muscle for small molecules with thermally modified fully porous particles</li>
</ul>

<h2 style="margin-top:40px; margin-bottom:5px;">Technical Guide Spotlight</h2>

<div class="col-2"><a href="/info/form/18dmguide"><img border="0" src="/webimage/275_metabolitesguide.png" width="145" /></a><br />
<a class="tech" href="/info/form/18dmguide">Drugs and Metabolism Guide »</a> </div>

<div class="col-2"><a href="/info/form/17uspguide"><img border="0" src="/webimage/2018uspguideshot.png" width="145" /></a><br />
<a class="tech" href="/info/form/17uspguide">USP/EP Guide »</a> </div>

<h2 style="margin-top:40px">Method Development and Product Selection</h2>

<div class="iselposter-det"><a href="/info/page/17pharmres" target="_blank">Explore the Pharmaceutical Resources Center »</a>

<p>Find the latest webinars, technical notes, and guides for pharmaceutical analysis.</p>
<a class="btn btn-small btn-primary" href="/info/page/17pharmres" style="margin-top:5px;" target="_blank">Learn more »</a> </div>
</div>

Featured

GUIDE

Improve Your USP and EP Monographs

Reduce run times, achieve higher resolution, and stay within Allowable Adjustments with this easy to navigate guide.
GUIDE

Improve Your UHPLC Column Selectivity

The Chromatographer's Guide to Improving UHPLC Column Selectivity. Finding the Right Tool for the Job.
TECHNICAL NOTE

Enhancing Sensitivities and Peak Capacities for UHPLC-MS Fast Gradient Analyses

Go beyond what is traditionally accepted for UHPLC runs with ultra-high efficiency and low backpressures.
VIDEO

The Value of Kinetex Core-Shell Technology

A look at core-shell technology and its impact on pharmacuetical HPLC.

Trending Applications

Trending Webinars and Webcasts

Frequently Asked Questions (FAQs) for Biomolecule Analysis

Quickly Analyze and Separate Biomolecules

In the biopharmaceutical industry, large molecules that interact with a biological system are all known as biomolecules. Examples of biomolecules include amino acids, peptides, proteins, antibodies, and DNA/RNA oligonucleotides.

Phenomenex offers a variety of specialized HPLC columns for the analysis and separation of biomolecules. In the case of protein analysis, our columns allow scientists to determine protein concentration, as well as the ability to scale up to protein purification. The columns designed for protein analysis contain silica particles with larger pore sizes so they can better interact with the biomolecules injected onto the column. It’s these interactions that separate the proteins to determine protein concentration and eventually scale the process up to protein purification.

Product Spotlight

bioZen UHPLC Columns »
Biocompatible LC columns for biologics analysis.

Method Development and Product Selection

BioSeparations Handbook »

Practical method development strategies to the challenges of characterization, isolation, and purification of biomolecules.

Download »

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<h2>Trending Applications</h2>

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	<li><a href="/Application/Detail/23218" target="_blank">Degraded Human Insulin »</a></li>
	<li><a href="/Application/Detail/23219" target="_blank">Human Insulin »</a></li>
	<li><a href="/Application/Detail/23247" target="_blank">Mouse Monoclonal Antibody »</a></li>
	<li><a href="/Application/Detail/23243" target="_blank">Protein Test Mix »</a></li>
</ul>

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	<li><a href="/Application/Detail/19824" target="_blank">Degraded Myoglobin »</a></li>
	<li><a href="/Application/Detail/20683" target="_blank">Bovine Ig-G »</a></li>
	<li><a href="/Application/Detail/22132" target="_blank">Peptide Mix »</a></li>
	<li><a href="/Application/Detail/19887" target="_blank">Protein Reduction Refold Assay »</a></li>
</ul>

<h2>Trending Webinars and Webcasts</h2>

<p class="webtitle"><a href="/info/form/2014gfcwebinar" target="_blank">Do I Really Know How Much Aggregate is in my Protein Therapeutic? »</a></p>

<p class="webtitle"><a href="/info/form/2013bioseminar" target="_blank">Method Development Strategies for Intact Protein Analysis by Reversed Phase and Gel Filtration Chromatography  »</a></p>

<h2>Frequently Asked Questions (FAQs) for Biomolecule Analysis</h2>

<ul class="ifaqs">
	<li><a href="/FAQ/Details/8b47f78d-d353-4f2f-93c3-5d4d1fcaec0a/what-is-an-acceptable-standard-to-use-for-lc-ms-method-development-for-oligonucle" target="_blank">What is an acceptable standard to use for LC/MS method development for oligonucleotides? »</a></li>
	<li><a href="/FAQ/Details/120cee9a-f9a3-48e7-9705-e7bcf1da7a8f/what-is-the-most-common-uv-wavelength-to-detect-proteins/" target="_blank">What is the most common UV wavelength to detect proteins? »</a></li>
	<li><a href="/FAQ/Details/b715593f-cef2-4735-9907-dbf5938f1579/in-gfc-what-is-a-chaotropic-agent-and-how-can-it-be-used-to-determine-the-molecu" target="_blank">In GFC, what is a chaotropic agent and how can it be used to determine the molecular weight of a protein? »</a></li>
</ul>

<hr />
<h2>Quickly Analyze and Separate Biomolecules</h2>

<p style="margin-top:-10px;">In the biopharmaceutical industry, large molecules that interact with a biological system are all known as biomolecules. Examples of biomolecules include amino acids, peptides, proteins, antibodies, and DNA/RNA oligonucleotides.</p>

<p>Phenomenex offers a variety of specialized HPLC columns for the analysis and separation of biomolecules. In the case of protein analysis, our columns allow scientists to determine protein concentration, as well as the ability to scale up to protein purification. The columns designed for protein analysis contain silica particles with larger pore sizes so they can better interact with the biomolecules injected onto the column. It’s these interactions that separate the proteins to determine protein concentration and eventually scale the process up to protein purification.</p>

<h2 style="margin-bottom:5px;">Product Spotlight</h2>

<div class="col-2" style="margin-top:15px"><a class="tech" href="/Products/detail/biozen">bioZen UHPLC Columns »</a><br />
Biocompatible LC columns for biologics analysis.</div>

<h2 style="margin-top:40px">Method Development and Product Selection</h2>

<div class="iselposter-det"><a href="/info/form/2013biobundlerequest" target="_blank">BioSeparations Handbook »</a>

<p>Practical method development strategies to the challenges of characterization, isolation, and purification of biomolecules.</p>
<a class="btn btn-small btn-primary" href="/info/form/2013biobundlerequest" style="margin-top:5px;" target="_blank">Download »</a> </div>
</div>

Featured

BROCHURE

Aeris Core-Shell Technology for Proteins and Peptides

A look at how core-shell technology can dramatically improve analysis of biomolecules
BROCHURE

Yarra: The New Standard in High Resolution Size Exclusion

Achieve high resolution GFC with Yarra SEC columns
TECHNICAL NOTE

Recommendations for Transferring Peptide Mapping Methods to LC/MS Using Core-Shell Columns

With the emergence of new protein therapeutics, including biosimilars, biobetters and ADCs, peptide mapping by LC/MS is becoming more commonly used for the identification of post-translational modifications (PTMs), glycosylation, and conjugation sites, as well as primary sequence confirmation.
TECHNICAL NOTE

Improving Intact Biogeneric Protein Separations

Improved resolution of proteins is accomplished with a new core-shell particle morphology which minimizes protein band broadening that occurs during diffusion in and out of the core-shell particle.

Trending Applications

Trending Webinars and Webcasts

LC Solutions for Improving Chiral Separation Success »

Frequently Asked Questions (FAQ) for Chiral Analysis

Achieve High Purity Chiral HPLC Separations

Effective chiral separations have become increasingly important to the pharmaceutical and biopharmaceutical industries. The rapid introduction of optically active medicinal drugs, along with increasing government regulation, necessitates that rapid, sensitive, and reliable stereochemical methods be devised for their analysis. Chiral chromatography is by far the most powerful and sensitive analytical technique for resolving enantiomers.

Phenomenex maintains a dedicated chiral screening services laboratory using our own chiral HPLC columns which can assist you in developing or improving your chiral separation. We can assist you in column selection, method development, scale up, or any other aspect of chiral chromatography.

Product Spotlight

Lux Chiral LC Columns »
Polysaccharide based chiral columns for effective screening under Reversed Phase, Polar Organic, Normal Phase, and SFC conditions.

Method Development and Product Selection

Lux i-Amylose-3 Screening Application Notebook »

Incredible Robustness
Expanded Versatility High
Enantioselectivity

Download »

<ul class="iapps" style="width:190px;">
	<li><a href="/Application/Detail/23142" target="_blank">Chlorpheniramine »</a></li>
	<li><a href="/Application/Detail/20099" target="_blank">Ketoprofen »</a></li>
	<li><a href="/Application/Detail/22013" target="_blank">Ifenprodil »</a></li>
	<li><a href="/Application/Detail/20544" target="_blank">Oxprenolol »</a></li>
</ul>

<ul class="iapps" style="width:190px;">
	<li><a href="/Application/Detail/23891" target="_blank">Nicardipine  »</a></li>
	<li><a href="/Application/Detail/21850" target="_blank">Triticonazole »</a></li>
	<li><a href="/Application/Detail/21806" target="_blank">Loctofen »</a></li>
	<li><a href="/Application/Detail/21762" target="_blank">Difenoconazole »</a></li>
</ul>

<h2>Trending Webinars and Webcasts</h2>

<p class="webtitle" style="margin-top: -7px"><a href="/info/form/19chiralseparationswebinar" target="_blank">LC Solutions for Improving Chiral Separation Success »</a></p>

<div class="clear"> </div>
	</li>
	
</ul>

<h2>Frequently Asked Questions (FAQ) for Chiral Analysis</h2>

<ul class="ifaqs">
	<li><a href="/FAQ/Details/02af32ad-a466-4f08-84b4-6f2c03ca96a3/how-can-i-reverse-enantiomeric-elution-order" target="_blank">How can I reverse enantiomeric elution order? »</a></li>
	<li><a href="/FAQ/Details/241bd2e4-d771-44f5-8b6a-5d5484c1bdda/how-do-aromatic-functionalities-in-chiral-compounds-affect-selectivity/" target="_blank">How do aromatic functionalities in chiral compounds affect selectivity? »</a></li>
	<li><a href="/FAQ/Details/9428420d-1769-4d5d-a1f4-3ca24f84d6c4/how-can-i-maintain-high-efficiency-during-scale-up-from-analysis-to-purification" target="_blank">How can I maintain high efficiency during scale up from analysis to purification? »</a></li>
</ul>

<hr />
<h2>Achieve High Purity Chiral HPLC Separations</h2>

<p style="margin-top:-10px;">Effective chiral separations have become increasingly important to the pharmaceutical and biopharmaceutical industries. The rapid introduction of optically active medicinal drugs, along with increasing government regulation, necessitates that rapid, sensitive, and reliable stereochemical methods be devised for their analysis. <a href="/chiral-hplc-column" target="_blank">Chiral chromatography</a> is by far the most powerful and sensitive analytical technique for resolving enantiomers.</p>

<p>Phenomenex maintains a dedicated chiral screening services laboratory using our own chiral HPLC columns which can assist you in developing or improving your chiral separation. We can assist you in column selection, method development, scale up, or any other aspect of chiral chromatography.</p>

<h2>Product Spotlight</h2>

<ul class="prodlight">
	<li class="luxonelc" style="width:315px;"><a href="/Products/HPLCDetail/lux" target="_blank"><img border="0" class="spotlightimg" id="chirallcpharm" src="/webimage/lux-amy-prep-side-by-side.png" width="95" /></a> <a class="tech" href="/Products/HPLCDetail/lux">Lux Chiral LC Columns »</a><br />
	Polysaccharide based chiral columns for effective screening under Reversed Phase, Polar Organic, Normal Phase, and SFC conditions.</li>
	<!--<li class="luxtwolc">
<a target="_blank" href="/Products/HPLCDetail/Yarra"><img border="0" id="yarrasecpharm" width="100" class="spotlightimg" src="/webimage/yarra_three_colum.png"/></a>
<a class="tech" href="/Products/HPLCDetail/Yarra">Yarra SEC Columns »</a><br/>
Aqueous GFC columns that provide the highest efficiencies and resolution for biomolecules

</li>-->
</ul>

<h2 style="margin-top:40px">Method Development and Product Selection</h2>

<div class="iselposter-det"><a href="/info/form/2019chiralnotebook" target="_blank">Lux i-Amylose-3 Screening Application Notebook »</a>

<ul style="padding-top: 28px">
	<li>Incredible Robustness</li>
	<li>Expanded Versatility High</li>
	<li>Enantioselectivity</li>
</ul>
<a class="btn btn-small btn-primary" href="/Info/Form/2019chiralnotebook" style="margin-top:5px;" target="_blank">Download »</a> </div>
</div>

Featured

BROCHURE

Affordable Chiral Columns, Brilliant Separation Power

Lux Replaces DAICEL CHIRALCEL and CHIRALPAK Columns at Substantial Cost Savings!
TECHNICAL NOTE

Reversed Phase Chiral LC/MS/MS of Stereoisomeric Pharmaceutical Compounds

Five different Lux polysaccharide-based chiral stationary phases were explored, demonstrating the feasibility of LC/MS/MS analysis of acidic pharmaceutical racemates.
TECHNICAL NOTE

Performance Evaluation of Immobilized and Coated Polysaccharide Chiral HPLC Columns

Comparison of two chiral stationary phases (Lux Cellulose-1 and CHIRALPAK®IB) with the chiral selector cellulose tris(3,5-dimethyl- phenylcarbamate)
POSTER

Chiral HPLC/SFC Method Development Poster

Access our simplified chiral HPLC/SFC column screening strategies.

Trending Applications

Trending Webinars and Webcasts

Basic HPLC Troubleshooting
and Column Care »

Frequently Asked Questions (FAQ) for Excipient Analysis

Reliable Excipient Analysis

Excipients are the inactive ingredients within a pharmaceutical formulation that hold the active pharmaceutical ingredient (API) and ensure the conveniently sized dose is delivered efficiently and effectively to the targeted area. Excipients are typically inert substances, but sometimes they can give adverse side effects. Modern pharmaceutical regulations require formulation analysis for all ingredients within a pharmaceutical drug to identify all excipient components and guarantee safety of the end product.

Formulation analysis can be achieved through several modes of chromatography including reversed phase, ion-exclusion, and size exclusion chromatography (SEC), which includes gel permeation chromatography (GPC) and gel filtration chromatography (GFC). We offer a wide breadth of products for reliable and reproducible excipient analysis.

Product Spotlight

Rezex Ion Exlusion Columns »
Provides excellent resolution for carbohydrates and organic acids
Phenogel GPC Columns »
High resolution and tight calibration curves for polymers and small organics

Method Development and Product Selection

Formulations Guide »

A complete guide to formulations analysis including Ph. Eur and USP recommendations

Download »

<ul class="iapps" style="width:260px;">
	<li><a href="/Application/Detail/21507" target="_blank">Binder:Polyethylene Glycol (PEG) »</a></li>
	<li><a href="/Application/Detail/21505" target="_blank">Binder:Polyvinylpyrrolidone (PVP, Povidone) »</a></li>
</ul>

<ul class="iapps" style="width:190px;">
	<li><a href="/Application/Detail/19824" target="_blank">Fillers:Sugar Alcohols »</a></li>
	
	<li><a href="/Application/Detail/23247" target="_blank">Coating:Cellulose Acetate »</a></li>
</ul>

<h2>Trending Webinars and Webcasts</h2>

<p class="webtitle"><a href="/info/form/16lccolumncarewebinar" target="_blank">Basic HPLC Troubleshooting<br />
	and Column Care »</a></p>

<h2>Frequently Asked Questions (FAQ) for Excipient Analysis</h2>

<ul class="ifaqs">
	<li><a href="/FAQ/Details/0f8adb35-34d7-400a-9ccf-5414cf7adbe9/what-are-the-most-common-causes-for-baseline-drift-with-ri-detectors/" target="_blank">What are the most common causes for baseline drift with RI detectors? »</a></li>
	<li><a href="/FAQ/Details/250c7195-f9fd-48d9-80f0-937edb624af4/what-cleaning-procedure-can-i-use-to-regenerate-my-gpc-column" target="_blank">What cleaning procedure can I use to regenerate my GPC column? »</a></li>
	<li><a href="/FAQ/Details/086688d6-4c67-423f-b5bd-4308cc3899a6/what-detectors-can-be-used-for-sugar-analysis/" target="_blank">What detectors can be used for sugar analysis? »</a></li>
</ul>

<hr />
<h2>Reliable Excipient Analysis</h2>

<p style="margin-top:-10px;">Excipients are the inactive ingredients within a pharmaceutical formulation that hold the active pharmaceutical ingredient (API) and ensure the conveniently sized dose is delivered efficiently and effectively to the targeted area. Excipients are typically inert substances, but sometimes they can give adverse side effects. Modern pharmaceutical regulations require formulation analysis for all ingredients within a pharmaceutical drug to identify all excipient components and guarantee safety of the end product.</p>

<p>Formulation analysis can be achieved through several modes of chromatography including reversed phase, <a href="/hplc-column/ion-exclusion-hplc-column">ion-exclusion</a>, and <a href="/size-exclusion-chromatography-column">size exclusion chromatography (SEC)</a>, which includes gel permeation chromatography (GPC) and gel filtration chromatography (GFC). We offer a wide breadth of products for reliable and reproducible excipient analysis.</p>

<h2>Product Spotlight</h2>

<ul class="prodlight">
	<li class="aerlc"><a href="/Products/HPLCDetail/rezex" target="_blank"><img border="0" class="spotlightimg" id="rezexlcpharm" src="/webimage/yarra_three_colum.png" width="100" /></a> <a class="tech" href="/Products/HPLCDetail/rezex">Rezex Ion Exlusion Columns »</a><br />
	Provides excellent resolution for carbohydrates and organic acids</li>
	<li class="yarragfc"><a href="/Products/HPLCDetail/phenogel" target="_blank"><img border="0" class="spotlightimg" id="phenogelgpcpharm" src="/webimage/yarra_three_colum.png" width="100" /></a> <a class="tech" href="/Products/HPLCDetail/phenogel">Phenogel GPC Columns »</a><br />
	High resolution and tight calibration curves for polymers and small organics</li>
</ul>

<h2 style="margin-top:60px">Method Development and Product Selection</h2>

<div class="iselposter-det"><a href="//phenomenex.blob.core.windows.net/documents/b70e1cca-3adc-4fb0-bbdf-54d1b6ed8fb1.pdf" target="_blank">Formulations Guide »</a>

<p>A complete guide to formulations analysis including Ph. Eur and USP recommendations</p>
<a class="btn btn-small btn-primary" href="//phenomenex.blob.core.windows.net/documents/b70e1cca-3adc-4fb0-bbdf-54d1b6ed8fb1.pdf" style="margin-top:5px;" target="_blank">Download »</a> </div>
</div>

Featured

GUIDE

Fast HPLC-UV Analysis of Tween 80 by SEC

Tween 80 is used as an emulsifier for dissolving oils, as well as a surfactant. In this application, Tween 80 is analyzed by HPLC-UV using a Yarra 1.8 μm SEC-X150 150 x 4.6 mm aqueous size exclusion (SEC), or gel filtration chromatography (GFC), column in under 12 minutes.
TECHNICAL NOTE

Analyzing Excipients by Gel Permeation Chromatography (GPC)

Analyzing Pharmaceutical Tablet and Capsule Excipients by Gel Permeation Chromatography (GPC) using Phenogel Columns.
TECHNICAL NOTE

Optimizing the Analysis of Sugar Alcohol Excipients in Pharmaceutical Tablet Formulations

Rezex RPM, RCM and RCU phases are well-suited for use in USP methodologies for the analysis of mannitol, sorbitol, xylitol, and other excipients.
TECHNICAL NOTE

Revised USP Chapter <467> and its Application to Excipient Qualification and Testing

A look at the impact of the revised USP Chapter <467>

Trending Applications

Trending Webinars and Webcasts

Frequently Asked Questions (FAQ) for Residual Solvent Analysis

Reliable Residual Solvent Testing and Confirmation

The USP has provided a method for the identification, control, and quantification of organic volatile impurities (OVIs) and Class 1 and 2 residual solvents, which specifies analytical procedures by GC/FID. Phenomenex offers G16 and G43 phases used in USP Monograph <467>, as well as a collection of tips, tools, and resources to improve and optimize residual solvent testing.

Product Spotlight

Zebron ZB-624 GC Column »
Offers improved separation for volatiles and polar compounds
Zebron ZB-WAXplus GC Columns »
Provides enhanced selectivity and is 100% aqueous stable

Method Development and Product Selection

Whitepaper: Understanding the Revisions
to USP Monograph <467>: Residual Solvents
Download »

<ul class="iapps" style="width:190px;">
	<li><a href="/Application/Detail/16348">Procedure A - Class 1 »</a></li>
	<li><a href="/Application/Detail/16349">Procedure A - Class 2 »</a></li>
</ul>

<ul class="iapps" style="width:190px;">
	<li><a href="/Application/Detail/16352">Procedure B - Class 1 »</a></li>
	<li><a href="/Application/Detail/16353">Procedure B - Class 2 »</a></li>
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<h2>Trending Webinars and Webcasts</h2>

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<h2>Frequently Asked Questions (FAQ) for Residual Solvent Analysis</h2>

<ul class="ifaqs">
	<li><a href="/FAQ/Details/ccffcccd-b384-4e63-bfc5-cb3bc72203d4/why-is-headspace-used-for-the-usp-chapter-467-residual-solvents-organic-volatile/" target="_blank">Why is headspace used for the USP Chapter 467 Residual Solvents/Organic Volatile Impurities method? »</a></li>
	<li><a href="/FAQ/Details/f81c3d97-c8bc-431a-8cd1-0e2633d0396b/what-solvents-do-i-have-to-analyze-using-usp-chapter-467-residual-solvents-organ" target="_blank">What solvents do I have to analyze using USP Chapter 467, Residual Solvents/Organic Volatile Impurities? »</a></li>
</ul>

<hr />
<h2>Reliable Residual Solvent Testing and Confirmation</h2>

<p style="margin-top:-10px;">The USP has provided a method for the identification, control, and quantification of organic volatile impurities (OVIs) and Class 1 and 2 residual solvents, which specifies analytical procedures by GC/FID. Phenomenex offers G16 and G43 phases used in USP Monograph <467>, as well as a collection of tips, tools, and resources to improve and optimize residual solvent testing.</p>

<h2>Product Spotlight</h2>

<ul class="prodlight">
	<li class="zebonegc"><a href="/Products/GCDetail/Zebron/ZB-624" target="_blank"><img border="0" class="spotlightimg" id="zeb-col-one" src="/webimage/big-gc-ring-tilt.png" width="45" /></a> <a class="tech" href="/Products/GCDetail/Zebron/ZB-624">Zebron ZB-624 GC Column »</a><br />
	Offers improved separation for volatiles and polar compounds</li>
	<li class="zebtwogc"><a href="/Products/GCDetail/Zebron/ZB-WAXplus" target="_blank"><img border="0" class="spotlightimg" id="zeb-col-two" src="/webimage/big-gc-ring-tilt.png" width="45" /></a> <a class="tech" href="/Products/GCDetail/Zebron/ZB-WAXplus">Zebron ZB-WAXplus GC Columns »</a><br />
	Provides enhanced selectivity and is 100% aqueous stable</li>
</ul>

<h2 style="margin-top:40px">Method Development and Product Selection</h2>

<div class="iselposter-det"><a href="/info/form/2014usp" target="_blank">Whitepaper: Understanding the Revisions<br />
to USP Monograph <467>: Residual Solvents</a><br />
<a class="btn btn-small btn-primary" href="/info/form/2014usp" style="margin-top:5px;" target="_blank">Download »</a> </div>
</div>

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