Chiral Supercritical Fluid Chromatography (SFC)

Separate Chiral Compounds

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<h1>Chiral Supercritical Fluid Chromatography (SFC)</h1>

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<p style="padding-left: 10px; font-size: 14px;"><a href="/Products/HPLCDetail/lux" style="font-size: 16px;"><span style="font-size: 20px;">•</span> Lux<sup>®</sup> Polysaccharide-Based Chiral SFC/HPLC Columns</a><br />
<strong>Complementary selectivities </strong>that allow you to screen for the most effective chiral separation under SFC conditions</p>

<p style="padding-top: 13px; padding-left: 10px; font-size: 14px;"><a href="/Products/HPLCDetail/lux" style="font-size: 16px;"><span style="font-size: 20px;">•</span> SecurityGuard<sup>®</sup> Universal Guard Cartridge System </a><br />
<strong>Extend the lifetime </strong>of your chiral SFC column</p>

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<h3>Chiral Supercritical Fluid Chromatography (SFC)</h3>

<p>Normal Phase is used to separate hydrophobic compounds and matrices that are retained too strongly by reversed phase and have minimal solubility in aqueous mobile phases.</p>

<p>Chiral supercritical fluid chromatography can be used to efficiently separate and purify enantiomers. SFC is similar to normal phase chromatography but instead incorporates pressurized carbon dioxide as the main component of the mobile phase. Since supercritical fluids are close to the critical point, small changes in temperature and pressure will cause large changes in density. These changes can have dramatic effects in selectivity and separation for chiral compounds.</p>

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Chiral HPLC/SFC Method Development Poster

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Chiral Column Care and Use Notes for SFC

Recommended instructions for the care and use of your Lux analytical column under SFC conditions (internal ID ≤ 4.6 mm)
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TECHNICAL NOTE

Technical Note for Novel Chiral Screening by SFC

Novel Screening Approach for the Separation of Pharmaceutical Compounds using Lux Polysaccharide-Based Chiral Stationary Phases in SFC Mode

AChiral Supercritical Fluid Chromatography (SFC)

Separate Hydrophobic Compounds

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Novel cross-linked diol phase

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Unique ether-linked phenyl phase

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Versatile PFP (pentafluorophenyl) phase

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Ultra-pure silica phase

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Robust amino phase

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Stable cyano phase

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<h1>AChiral Supercritical Fluid Chromatography (SFC)</h1>

<ul style="margin-left: 10px;">
	<li class="sec-sub-list">Separate Hydrophobic Compounds</li>
</ul>

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<p style="padding-left: 10px; font-size: 14px;"><a href="/Products/Detail/Luna/HILIC" style="font-size: 16px;"><span style="font-size: 20px;">•</span> Luna<sup>®</sup> HILIC</a><br />
Novel cross-linked diol phase</p>

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Unique ether-linked phenyl phase</p>

<p style="padding-top: 13px; padding-left: 10px; font-size: 14px;"><a href="/Kinetex/Selectivities" style="font-size: 16px;"><span style="font-size: 20px;">•</span> Kinetex<sup>®</sup></a><br />
Versatile PFP (pentafluorophenyl) phase</p>
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Ultra-pure silica phase</p>

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Robust amino phase</p>

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Stable cyano phase</p>
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<p style="padding-top: 13px; padding-left: 10px; font-size: 14px;"><a href="/Products/HPLCDetail/SecurityGuard%20Standard" style="font-size: 16px;"><span style="font-size: 20px;">•</span> SecurityGuard<sup>®</sup> Universal Guard Cartridge System </a><br />
<strong>Extend the lifetime </strong>of your achiral SFC columns</p>

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<h3>Achiral Supercritical Fluid Chromatography (SFC)</h3>

<p>Supercritical fluid chromatography (SFC) is predominately used for low to moderate molecular weight compounds and can provide significant advantages in selectivity since mobile phase density directly impacts the affinity of the mobile phase for target analytes.</p>

<p>We offer a full line of unique selectivities designed to offer very different interactions with analytes under supercritical fluid chromatography (SFC) conditions.</p>

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Achiral SFC HPLC Column Selection

Achiral Stationary Phase Selectivity under Supercritical Fluid Chromatography (SFC) Conditions
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Preparative Supercritical Fluid Chromatography (SFC)

Large Scale Purification

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<h1>Preparative Supercritical Fluid Chromatography (SFC)</h1>

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<p style="padding-left: 10px; font-size: 14px;"><a href="/Products/Preparative" style="font-size: 16px;"><span style="font-size: 20px;">•</span> Axia ™ Packed Preparative SFC/HPLC Columns</a><br />
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<h3>Preparative Supercritical Fluid Chromatography (SFC)</h3>

<p>Preparative supercritical fluid chromatography (SFC) offers significant advantages in sample recovery, faster and easier fraction collection due to reduced sample volume, and cost reduction in the use of organic solvents.  Preparative SFC is becoming more popular for chiral purification as well as achiral small molecule purification.</p>

<p>We provide a full suite of chiral and achiral axial-packed preparative SFC columns available in 21.2 mm, 30 mm and 50 mm IDs for small to medium scale preparative supercritical fluid chromatography.</p>

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Excellent Axia pre-packed preparative HPLC/SFC columns

Available in over 40 unique achiral and chiral selectivities, Axia PREP LC columns offer:

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Chiral Supercritical Fluid Chromatography (SFC)

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