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Aeris HPLC Information


UHPLC/HPLC Core-Shell Technology for BioSeparations

Core-shell particle technology provides striking increases in peak capacity and resolution at lower backpressure, giving chromatographers the ability to achieve ultra-high performance on ANY system, from  UHPLC to HPLC to PREP.

A uniform porous silica layer is grown around a solid, spherical silica core, providing effective retention and selectivity with improved resolution, speed, and recovery. Next, optimizing the pore size and shell thickness for intact proteins or smaller peptide fragments provides well-defined depth penetration of biomolecules leading to maximum separation power.

TEM and SEM of Aeris PEPTIDE 3.6 µm Core-Shell Particles

The precise architecture of core-shell particles provides dramatic leaps in performance in TWO important ways:

The thin, porous layer, or "shell", decreases the diffusion path length, thus reducing the time it takes for biomolecules to adsorb/desorb into and out of the particles.
 
Uniform sizing and shape of the particles along with tight packing specifications reduces losses in efficiency and performance due to band broadening.
 

The result is:

  • 3.6 µm and 2.6 µm core-shell particles that can perform like sub-2 μm columns on both HPLC and UHPLC systems at a fraction of the pressure
  • 2.6 µm and 1.7 µm core-shell particles that can provide higher peak capacities compared to fully porous sub-2 μm columns on UHPLC systems
0 Phases

WIDEPORE C4


WIDEPORE C4 Phase Information


Low Hydrophobicity Recommended for:

  • Very large proteins
  • Very hydrophobic proteins
  • Membrane proteins
  • Least retentive
0 Phases

Proteins


0 Phases

Peptides


0 Phases
Document Type:
Document Type Title
Technical Notes Intact IgG Separations by HPLC/UHPLC (TN-1110) Add to My Documents
Supporting Docs Aeris Column Care Note Add to My Documents
Brochures Aeris Core-Shell Technology for Proteins and Peptides Add to My Documents
Brochures Axia- The Ultimate Pre-packed Preparative Column Add to My Documents
Other Cross Reference Guide By Supplier - Landscape View Add to My Documents
Other HPLC/UHPLC Column Phase Selection Chart Add to My Documents
Brochures Improve Your Bioanalytical Assays Today Add to My Documents
Technical Notes Intact Biogeneric Protein Separations by HPLC/UHPLC (TN-1111) Add to My Documents
Webinar On-Demand BioSeparations Webinar from Phenomenex and C&E News Add to My Documents
Brochures Online BioSeparations Handbook Add to My Documents
Other Pharmaceutical Analysis Guide- Formulations Add to My Documents
Brochures SecurityGuard Column Protection Family Brochure (UHPLC, HPLC, PREP, SFC) Add to My Documents
Other THE Clinical Application Notebook, Volume 2 Add to My Documents
Technical Notes Post-Translational Modifications of Intact IgG by HPLC/UHPLC and GFC/SEC (TN-1118) Add to My Documents
Technical Notes Intact IgG by HPLC/UHPLC (TN-1123) Add to My Documents
Technical Notes Peptide Mapping by HPLC (TN-1124) Add to My Documents
Webinar Webinar White Paper: Transform Your Mindset for HPLC and UHPLC Method Development For Analyzing Proteins- Including Monoclonal Antibodies Add to My Documents
Supporting Docs Aeris Column Care Guide Add to My Documents
Technical Notes Goserelin (peptide) from Serum using Microelution SPE and LC/MS/MS Analysis Add to My Documents
Supporting Docs Important Tips for Optimizing Aeris Add to My Documents
Technical Notes LC-MS/MS Analysis of Immunosuppressants from Whole Blood (TN-1169) Add to My Documents
Technical Notes Recommendations for Transferring Peptide Mapping Methods to LC/MS Using Core-Shell Columns (TN-1181) Add to My Documents
MSDS Safety Data Sheet for Silica-Based HPLC Columns Add to My Documents
Brochures SecurityGuard ULTRA Brochure Add to My Documents
Other Allowable Adjustments to European Pharmacopoeia (EP) Methods Add to My Documents
Supporting Docs Meeting All Your PREP Needs Add to My Documents
Supporting Docs Meeting All Your SFC Needs Add to My Documents
Other Protein and Peptide Users Guide Add to My Documents
Technical Notes SecurityGuard ULTRA Dramatically Extends UHPLC Column Lifetimes (TN-1125) Add to My Documents
Supporting Docs HPLC Column Care Guide Add to My Documents
Phase: Particle Size: Pore Size: Length: Internal Diameter:
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Part Number:00D-4486-AN

Description:Aeris™ 3.6 µm WIDEPORE C4 200 Å, LC Column 100 x 2.1 mm, Ea

Required Holder:

Stationary Phase:

Solid Support:Core-shell Silica*

Format:Column

Separation Mode:Reversed Phase

Recommended Use:Proteins, Antibodies, Large Peptides

USP Designation:


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