Basic Compounds by LC/MS using High pH Mobile Phase (TN-1031)

Abstract:

We investigated the effectiveness of using high pH mobile phases for the quantitation of basic compounds in ESI+ LC/MS/MS by comparing limits of detection (LOD), limits of quantitation (LOQ), linearity ranges, precision and accuracy observed in high and low pH mobile phases.

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical

Techniques:

HPLC / UHPLC

Brands:

Gemini

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