A Unified Sample Preparation Procedure for General Unknown Screening (GUS) of Compounds in Whole Blood Samples
- Abstract:
- The identification of drugs from whole blood by high resolution mass spectrometer serves as an effective screening tool in both clinical and forensic labs. In addition, whole blood presents a challenging matrix that often requires an elaborate sample preparation procedure. The objectives of this work was to: • Develop a universal sample preparation procedure for whole blood samples to: lyse the erythrocytes, precipitate the majority of plasma proteins, and remove high levels of phopholipids present in the sample • Neutralize the undesirable effect of strong solvent
- Document Type:
- Technical Notes
- Industries:
- Clinical Forensics/Toxicology
- Techniques:
- HPLC / UHPLC Sample Prep
- Brands:
- Kinetex Phree
- PDF Link:
- Click here