Aggregate Analysis of Fc-Fusion Proteins using a Biozen dSEC-2 LC Column

Abstract:

Fc-fusion proteins are Fc homodimers linked to a polypeptide chain. From an analytical standpoint, Fcfusion proteins present several challenges. Fc-fusion proteins may have much more complex glycosylation, including deviations from the biantennary fucosylated glycans associated with monoclonal antibodies, as well as O-glycans.

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical

Techniques:

HPLC / UHPLC

Brands:

bioZen

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