Analysis of Antibody Drug Conjugates (ADCs) using High Efficiency Gel Filtration Columns (TN-1176)

Abstract:

Gel filtration chromatography is a common method used for the analysis of macromolecules, including antibody drug conjugates (ADCs). This presents unique challenges since ADCs are more hydrophobic than their parent monoclonal antibodies mAbs). In this study, we investigate the feasibility of using a non-toxic ADC model with a Yarra™ 3 μm SEC-3000 column for aggregate analysis.

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical Life Science

Techniques:

HPLC / UHPLC

Brands:

Yarra

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