Analysis of Paracetamol and Critical Impurities Under European Pharmacopoeia Conditions Utilizing a Kinetex® 2.7µm C18 Core-Shell LC Column

Abstract:

In this technical note, utilizing a Kinetex 2.7µm C18 100 x 2.1 mm column, we were able to provide acceptable, reproducible resolution for paracetamol and the principal degradation product impurity K by using the specific HPLC parameters (particle size, column dimension, and gradient mobile phase conditions) consistent with the Ph. Eur. impurities test for paracetamol published in Supplement 9.4.2-3 The Kinetex 2.7µm C18 column we used is a direct equivalent to the specified suitable column in Pharmeuropa 28.1 revision.

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical

Techniques:

HPLC / UHPLC

Brands:

Kinetex

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