Chiral Separation of Naproxen by High Performance Liquid Chromatography on Lux i-Amylose-1

Abstract:

In this technical note, we report the chiral separation of racemic Naproxen using the immobilized polysaccharide-based chiral stationary phase Lux i-Amylose-1. Under optimal conditions, the racemic Naproxen was efficiently separated with a resolution factor of 2.33 and a separation factor (alpha) of 1.16. This method can be used for the enantiomeric separation and purity assessment of S-Naproxen, the Active Pharmaceutical Ingredient (API).

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical

Techniques:

HPLC / UHPLC

Brands:

Lux SecurityGuard Standard

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