Comparison of Two High-Performance Particle Morphologies in the Separation of Hydrochlorothiazide and Chlorothiazide

Abstract:

In this application, we build upon previous work and explore the high-performance separation of hydrochlorothiazide and chlorothiazide with two different LC column particle morphologies. Under the same system and method conditions we compared a traditional Fully Porous 5 µm C18 to both a thermally modified Fully Porous Luna Omega 5 µm C18 and a Core-Shell Kinetex 5 µm C18 of identical dimensions.

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical

Techniques:

HPLC / UHPLC

Brands:

Kinetex Luna

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