Determination of Chloroquine, Hydroxychloroquine and its Metabolite Desethyl Hydroxychloroquine in Plasma Samples by LC-MS/MS

Abstract:

The World Health Organization (WHO) has initiated together with the local Health Ministries of many countries clinical studies to evaluate possible treatments for COVID-19. Two of the drugs which are being tested are Chloroquine (CQ) and Hydroxychloroquine (HCQ). This application note describes the analysis of these two drugs together with the metabolite Desethyl Hydroxychloroquine (DHCQ) from various biological matrices. The method was developed by Dr. Thomas Lanot from the Institut Fédératif de Biologie–CHU de Toulouse in France. The isocratic method allows for a fast and reliable quantification with a LOQ of 10 μg/L.

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical

Techniques:

HPLC / UHPLC

Brands:

Kinetex

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