Dicamba and Acidic Herbicides by LC-MS/MS

Abstract:

Historically, the analysis of acidic herbicides (AcHs) has been performed using a complex sample preparation procedure to derivatize the analytes followed by detection with gas chromatography and an electron capture detector. The US EPA Method 8151: CHLORINATED HERBICIDES BY GC USING METHYLATION OR PENTAFLUOROBENZYLATION DERIVATIZATION has been the most common analytical approach for these analytes. This method, however, is extremely difficult to perform correctly, is not rugged, and is time consuming. LC-MS/MS as a replacement technology would eliminate the need for the derivatization step thus making this a more rugged analytical approach. A recent literature review of chlorophenoxy acid herbicide methods demonstrated that LC-MS/MS was the prevalent technology cited. Acidic functional groups are easiest to ionize as their conjugate base, and LC-MS/MS methods can utilize negative mode electrospray ionization (ESI−) with great sensitivity.

Document Type:

Technical Notes

Industries:

Environmental Food & Beverage

Techniques:

HPLC / UHPLC

Brands:

Kinetex

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