Ibuprofen from Human Plasma by Supported Liquid Extraction (SLE) and LC-MS/MS (TN-1242)

Abstract:

For a new generic drug product, several time points across multiple patient samples would be required for analysis to demonstrate bio-equivalence. These experiments are a significant undertaking for any company. In order to be effective, an efficient method with a short analysis time is highly preferred. We demonstrate an LC-MS/MS assay with a total run time of 2 minutes using Kinetex C18 2.6 μm, 50 x 2.1 mm column. The sample extraction with Strata DE supported liquid extraction 96-well plate is an automation friendly format, which is ideally suited for a bio-equivalence study.

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical

Techniques:

HPLC / UHPLC Sample Prep

Brands:

Kinetex Strata

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