mRNA Cap Purity Analysis on a Biozen Oligo Column

Abstract:

In this application note, mRNA oligonucleotide strands of 1250 nucleotides was enzymatically digested with Rnase H and injected into a Biozen 2.6 μm Oligo column. We present a Liquid Chromatography (LC) approach paired with high resolution mass spectrometry (HRMS) to distinguish a pool of multiple caps and their relative integrity

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical

Techniques:

HPLC / UHPLC

Brands:

bioZen

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