Quantitative Analysis of Cocaine Metabolites and Adulterants in Oral Fluid (TN-0122)

Abstract:

Oral fluid, being a non-intrusive form of biological sample collection, becomes a preferred choice for drug testing cases especially where drivers are under the influence (DUID). For testing cocaine metabolites (benzoylecgonine, cocaethylene, norcocaine) along with its most common adulterants, a polymeric strong cation-exchange SPE sorbent, Strata-X-C, was utilized for sample extraction and clean-up of cocaine-positive samples followed by LC-MS/MS analysis using a Kinetex 2.6 μm XB-C18 LC column in conjunction with a SCIEX 5000 Triple Quad mass spec.

Document Type:

Technical Notes

Industries:

Forensics/Toxicology

Techniques:

HPLC / UHPLC Sample Prep

Brands:

Strata-X Kinetex

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