Rapid Sample Extraction of Chloroquine, Hydroxychloroquine, and Desethylchloroquine from Serum for LC-MS/MS Analysis

Abstract:

In this fast analysis, a direct, in-plate protein precipitation and filtration is applied to increase the throughput of LC-MS/MS measurement for chloroquine, hydroxychloroquine and the metabolite desethylchloroquine from serum. The automatable sample extraction procedure produced excellent recovery values.

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical Clinical

Techniques:

HPLC / UHPLC Sample Prep

Brands:

Impact Kinetex

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