Robust Separation of Hydroxychloroquine and Chloroquine in Hydroxychloroquine Sulfate Tablets Using the Kinetex® 5 µm C18

Abstract:

In this application is the comparison of two particle morphologies of similar L1 (C18) phase in the separation of Hydroxychloroquine and related impurity Chloroquine under the USP conditions for assay of hydroxychloroquine sulfate tablets. The application demonstrates the potential method improvements that can be achieved per the allowable adjustments outlined in USP General Chapter <621> relative to the original column and conditions referenced in the monograph.

Document Type:

Technical Notes

Industries:

Pharmaceutical/Biopharmaceutical

Techniques:

HPLC / UHPLC

Brands:

Kinetex

PDF Link:

Click here